Author

John Frederick Hilton

Ottawa HospitalORCID 0000-0002-6280-8633Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Armaghan SarvariD· 1 shared Auden Hafezi· 1 shared Damian YapiD· 1 shared Daniel LaiiD· 1 shared Dave W. CesconiD· 1 shared Elena ZaikovaiD· 1 shared Jay Tan· 1 shared Karen A. GelmoniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Armaghan SarvarORCID

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1 paper

Recent·Most cited

The UV potentiated mutational signature of clinical stage G-quadruplex binder CX5461.

Elena Zaikova, Damian Yap, Armaghan Sarvar, Auden Hafezi, Jay Tan, Viviana Cerda, Kaylee Li, Daniel Lai, Karen A. Gelmon, John Frederick Hilton, Lesley Seymour, Peter C. Stirling, Dave W. Cescon, Samuel A. J. R. Aparicio

The paper investigates the mutational signature of CX5461, a photosensitiser, when combined with UVA light, showing increased SNV burden only in co-exposed cells.

bioRxiv · Apr 14, 2026 · PreprintCancer Biology