Viviana Cerda

G4SCOPE identifies sequence features and epigenetic contexts of chromatin G-quadruplexes

G4SCOPE predicts chromatin G-quadruplex occupancy from DNA sequence, revealing epigenetic differences in BRCA1 and BRCA2 deficient cells.

The UV potentiated mutational signature of clinical stage G-quadruplex binder CX5461.

The paper investigates the mutational signature of CX5461, a photosensitiser, when combined with UVA light, showing increased SNV burden only in co-exposed cells.

Somatic copy number mutations contribute to fitness in transplantation models of spontaneous human breast cancer metastasis

This study shows that somatic copy number mutations (CNA) influence metastatic fitness in breast cancer by mediating transcriptional changes and affecting clone survival in different sites.

Single cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancers

The paper identifies genomic and non-genomic contributions to drug resistance in triple negative breast cancer using single cell transcriptomics and copy number data.

Machine learning guided signal enrichment for ultrasensitive plasma tumor burden monitoring

This paper introduces MRD-EDGE, a machine learning platform for ultrasensitive ctDNA detection in plasma WGS, showing improved sensitivity and broader applicability for MRD monitoring.