Author

Jay Tan

BC Cancer Agency

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Armaghan SarvariD· 2 shared Damian YapiD· 2 shared Daniel LaiiD· 2 shared Elena ZaikovaiD· 2 shared Samuel A. J. R. AparicioiD· 2 shared Alexander Adrian-Hamazaki· 1 shared Amelia RichteriD· 1 shared Andy Mungall· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Armaghan SarvarORCID

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2 papers

Recent·Most cited

Chromosomal mutational signatures of DNA damaging agents at single cell resolution

Mirela Andronescu, Alexander Adrian-Hamazaki, Damian Yap, William Daniels, Armaghan Sarvar, Elena Zaikova, Benjamin Furman, Vinci Au, Amelia Richter, Michael Van Vliet, Caroline Baril, Beixi Wang, Sean Beatty, Farhia Kabeer, Ciara H. O’Flanagan, , Samuel A. J. R. Aparicio

This paper develops a framework to analyze chromosomal mutational patterns at single-cell resolution, revealing drug-induced mutational signatures in human tissues.

bioRxiv · Sep 7, 2026 · PreprintCancer Biology

The UV potentiated mutational signature of clinical stage G-quadruplex binder CX5461.

Elena Zaikova, Damian Yap, Armaghan Sarvar, Auden Hafezi, Jay Tan, Viviana Cerda, Kaylee Li, Daniel Lai, Karen A. Gelmon, John Frederick Hilton, Lesley Seymour, Peter C. Stirling, Dave W. Cescon, Samuel A. J. R. Aparicio

The paper investigates the mutational signature of CX5461, a photosensitiser, when combined with UVA light, showing increased SNV burden only in co-exposed cells.

bioRxiv · Apr 14, 2026 · PreprintCancer Biology