ATM functions as a rheostat of metabolic stress in small-cell lung cancer
Debdatta Halder, Utsav Sen, Vrinda Jethalia, Subhamoy Chakraborty, Andrew Elliott, Kedwin Ventura, Ari VanderWalde, Balazs Halmos, Hossein Borghaei, Tin Htwe Thin, Alan Soto, Mirela Berisa, Rachel Brody, Deniz Demircioglu, Dan Hasson, Triparna Sen
This study shows ATM regulates metabolic stress in SCLC by affecting ATF4 and MYC, leading to ferroptotic cell death and revealing a new therapeutic target.
bioRxiv · Mar 17, 2026 · PreprintCancer Biology