BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice
C.Y. Daniel Lee, Amberlene J. De La Rocha, Kellie Inouye, Peter Langfelder, Anthony Daggett, Xiaofeng Gu, Lu-Lin Jiang, Zoe Pamonag, Raymond Vaca, Jeffrey Richman, Riki Kawaguchi, Fuying Gao, Huaxi Xu, X. William Yang
This study shows that TREM2-R47H reduces amyloid plaques but fails to improve cognitive deficits or microglial reactivity in 5xFAD mice.
bioRxiv · Aug 3, 2023 · PreprintNeuroscience