Raymond Vaca

Large-scale Perturbation of Systems Biology-Derived Genes Reveals Modifiers of HD-associated Transcriptomic Networks and Pathology

The paper uses genetic perturbations to identify modifiers of HD-associated transcriptomic networks and pathology in mice and patient-derived neurons.

Dendritome Mapping Unveils Spatial Organization of Striatal D1/D2-Neuron Morphology

The paper introduces a pipeline to profile dendritic morphology of genetically-defined single neurons in the mouse brain, revealing morphological modules and age- or HD-associated changes.

Msh3 and Pms1 Set Neuronal CAG-repeat Migration Rate to Drive Selective Striatal and Cortical Pathogenesis in HD Mice

This study identifies Msh3 and Pms1 as genetic drivers of CAG-repeat migration in HD mice, leading to selective striatal and cortical pathogenesis.

BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice

This study shows that TREM2-R47H reduces amyloid plaques but fails to improve cognitive deficits or microglial reactivity in 5xFAD mice.