Peter Langfelder

The paper uses genetic perturbations to identify modifiers of HD-associated transcriptomic networks and pathology in mice and patient-derived neurons.

This study compares striatal pathology in SCA1 and HD mice, finding shared and distinct molecular and functional deficits in Medium Spiny Neurons.

The paper introduces a pipeline to profile dendritic morphology of genetically-defined single neurons in the mouse brain, revealing morphological modules and age- or HD-associated changes.

This study identifies Msh3 and Pms1 as genetic drivers of CAG-repeat migration in HD mice, leading to selective striatal and cortical pathogenesis.

This study shows that TREM2-R47H reduces amyloid plaques but fails to improve cognitive deficits or microglial reactivity in 5xFAD mice.

The paper shows that stronger systemic and liver immune responses improve liver cancer outcomes by reducing tumor burden and correlating with better survival.