Precision targeting of autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells
Jin Liu, Yuanxuan Xia, Brian J. Mog, Colin R. Gliech, Elana R. Shaw, Dylan P. Ferris, Abigail McGahan, Kennedy A Cleage, Brock Moritz, Kyle J. Kaeo, Tolulope O. Awosika, Sarah R. DiNapoli, Stephanie A. Glavaris, Xuyang Li, Nikita Marcou, , Maximilian F. Konig
This study develops anti-9G4 CAR-T and TCR-T cells to selectively target autoreactive B cells in SLE, reducing immunosuppression and cytokine toxicity.
bioRxiv · Oct 19, 2025 · PreprintImmunology