Nikita Marcou

The paper designs an AND-gated CAR T cell receptor called MANTIS that uses extracellular size differences to spatially regulate signaling for precise antigen recognition.

This study develops anti-9G4 CAR-T and TCR-T cells to selectively target autoreactive B cells in SLE, reducing immunosuppression and cytokine toxicity.

The paper compares ChIP-seq and ChEC-seq2 methods to study yeast RNA polymerase II transcription kinetics, finding that ChEC-seq2 better captures promoter and enhancer-bound RNAPII and enables kinetic modeling.

The paper identifies Crm1 as an adaptor that links transcription factors to chromatin at the nuclear pore complex, facilitating enhancer docking.