Colin R. Gliech

This study develops anti-9G4 CAR-T and TCR-T cells to selectively target autoreactive B cells in SLE, reducing immunosuppression and cytokine toxicity.

The paper reports cryo-EM structures of Haspin kinase bound to a nucleosome, revealing its unique DNA supergroove binding mechanism for phosphorylating H3T3.

This study shows that HYLS1 mutations cause centriole structural defects leading to ciliary dysfunction and developmental issues in mice, mirroring human Hydrolethalus Syndrome.