Author

Kent L. Leslie

Amylyx Pharmaceuticals, Inc. (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Anton M. SimeonoviD· 1 shared CRIS M. BROWN· 1 shared Fumihiko UranoiD· 1 shared Giovanni ManfrediiD· 1 shared Hibiki KawamataiD· 1 shared Jalia Dash· 1 shared Jasmine A. Fels· 1 shared Jeffrey R. MillmaniD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Anton M. SimeonovORCID

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2 papers

Recent·Most cited

Effects of the investigational drug sodium phenylbutyrate-TUDCA (AMX0035) on the transcriptional and metabolic landscape of sporadic ALS fibroblasts

Jasmine A. Fels, Jalia Dash, Kent L. Leslie, Giovanni Manfredi, Hibiki Kawamata

This study examines the effects of AMX0035 on the transcriptomic and metabolomic profiles of sporadic ALS fibroblasts, finding that the combination treatment alters more genes and metabolites than individual components.

bioRxiv · May 2, 2022 · PreprintNeuroscience

Genotype-phenotype correlation analysis and therapeutic development using a patient stem cell-derived disease model of Wolfram syndrome

Rie Asada Kitamura, Kristina G. Maxwell, Wenjuan Ye, Kelly Kries, CRIS M. BROWN, Punn Augsornworawat, Yoel Hirsch, Martin M. Johansson, Tzvi Weiden, Joseph Ekstein, Joshua N. Cohen, Justin B. Klee, Kent L. Leslie, Anton M. Simeonov, Mark J. Henderson, , Fumihiko Urano

This study uses a patient-derived stem cell model to show that a specific WFS1 variant causes mild Wolfram syndrome, which can be treated with chemical chaperones.

bioRxiv · Nov 7, 2021 · PreprintGenetics