Author

Kiito Otsubo

National Institute of Genetics

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:Drosophila· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Kuniaki SaitoiD· 3 shared Hideki NoguchiiD· 2 shared Keita MiyoshiiD· 2 shared Makoto TerauchiiD· 2 shared Masato T. KanemakiiD· 2 shared Ban SatoiD· 1 shared Daisuke SaitoiD· 1 shared Masayuki MiuraiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

Kuniaki SaitoORCID

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3 papers

Recent·Most cited

m1A58 governs two steps of human initiator-methionine tRNA metabolism: maturation and XRN2-mediated decay

Kiito Otsubo, Mio Nagura, Makoto Terauchi, Hideki Noguchi, Masato T. Kanemaki, Keita Miyoshi, Kuniaki Saito

This study shows m1A58 regulates tRNA maturation and XRN2-mediated decay in human cells, maintaining tRNA homeostasis.

bioRxiv · May 29, 2026 · PreprintBiochemistry

The mammalian rapid tRNA decay pathway is critical for N⁷-methylguanosine-hypomodified tRNA degradation under physiological conditions

Keita Miyoshi, Kiito Otsubo, Shunya Kaneko, Makoto Terauchi, Yuki Hatoyama, Hideki Noguchi, Masato T. Kanemaki, Kuniaki Saito

The paper shows that XRN2-dependent decay of mG-hypomodified tRNAs occurs under physiological conditions and is conserved across species.

bioRxiv · Nov 5, 2025 · PreprintMolecular Biology

Repressive S-adenosylmethionine biosynthesis status inhibits transcription of HeT-A retrotransposon in the germline of Drosophila.

Yoshiki Hayashi, Shinjiro Hino, Tetsuya Sato, Soshiro Kashio, Kiito Otsubo, Kuniaki Saito, Ban Sato, Natsuko Kawano, Daisuke Saito, Masayuki Miura, Mikita Suyama, Mitsuyoshi Nakao, Satoru Kobayashi

The paper shows that repressive SAM biosynthesis in Drosophila germline inhibits HeT-A retrotransposon transcription via 6mA methylation.

The Journal of Biochemistry · Jul 2, 2025Peer-reviewedDevelopmental Biology