Michael Schoof

FGF signaling induces disease-associated oligodendrocyte states and drives myelin pathology

This study shows FGF signaling induces disease-associated oligodendrocyte states and causes myelin pathology in both in vitro and in vivo models.

An atlas of the aging glycoproteome reveals how glycosylation modulates autoantibody binding in the brain

The paper maps age-related changes in the N-glycoproteome across multiple tissues in mice, showing how glycosylation affects autoantibody binding to MOG in the brain.

Domain-specific proteome remodeling defines mouse myelin aging

This study identifies age- and sex-related changes in the mouse myelin proteome, revealing increased structural proteins and decreased cytoskeletal and synaptic proteins with aging.

Stereoselective methyl-swapping demonstrates target specificity of cognitive enhancer

The paper demonstrates that a modified ISRIB analog selectively targets a mutant eIF2B, improving synaptic plasticity and memory in mice, confirming its on-target mechanism.

Discovering Glycosylation-Dependent Protein Function by Thermal Proteome Profiling

The paper uses thermal proteome profiling to study how glycosylation affects protein function and stability, finding that sialylation and fucosylation perturbations significantly impact cell surface protein interactions.

A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation

The paper shows how a point mutation in eIF2B's β subunit mimics eIF2-P binding, leading to constitutive activation of the integrated stress response through an I-State conformation.

GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control

The paper identifies GIGYF2 and 4EHP as translation inhibitors that suppress re-initiation of defective mRNAs, aiding ribosome-associated quality control and preventing toxic protein accumulation.

Chromatin accessibility is dynamically regulated across C. elegans development and ageing

The paper maps regulatory elements across C. elegans development and ageing, identifying promoters and enhancers and showing their dynamic accessibility linked to developmental processes.