Limited microglial metabolic improvement with time-restricted feeding in diet-induced obesity
Han Jiao, Jarne Jermei, Xian Liang, Hendrik J.P. van der Zande, Frank Vrieling, Valentina Sophia Rumanova, Milan Dorscheidt, Felipe Corrêa‐da‐Silva, Anhui Wang, Ewout Foppen, Alberto M. Pereira, Dirk Jan Stenvers, TieMin LIU, Kimberly Bonger, Rinke Stienstra, , Chun‐Xia Yi
This study examines how time-restricted feeding affects microglial immunometabolism in obese rats, finding that TRF during the active phase reduces fat mass and alters microglial transcriptome rhythmicity, but does not reverse HFD-induced metabolic inflexibility.
Cell Reports · Oct 1, 2025Peer-reviewedImmunology