Andries Kalsbeek

This paper models the effect of V1a receptor antagonism on circadian rhythms in mice, showing it accelerates resynchronization and suggests therapeutic potential for circadian disorders.

This study examines how time-restricted feeding affects microglial immunometabolism in obese rats, finding that TRF during the active phase reduces fat mass and alters microglial transcriptome rhythmicity, but does not reverse HFD-induced metabolic inflexibility.

The paper examines neuropathological changes in the nucleus basalis of Meynert in diabetes patients, finding reduced ChAT expression in T1DM and increased hyperphosphorylated-Tau in T2DM.

This study shows that activating microglial PPARdelta with GW0742 improves insulin sensitivity in obese rats without changing body weight or food intake.

This study creates a detailed single-cell RNA-seq atlas of the mouse PVN, identifying transcriptional subtypes and linking them to functional roles.