Targeted degradation of GSPT1 and NEK7 by a molecular glue prodrug for treatment of HCC
Przemysław Glaza, Roman Pluta, Krzysztofa E. Odrzywół, Marta Klejnot, Maria Wieczorek, Sylvain Cottens, Donald Coppen, Paweł Dobrzański, Tomáš Drmota, Joanna Lis-Grześniak, Agata Śnieżewska, Joanna Majkut, Martyna Mianowska, Paulina Rozborska, Marta Jarmuszkiewicz, , Michał Walczak
The paper identifies ABS-752, a molecular glue prodrug that degrades GSPT1 and NEK7 in HCC cells, showing potent in vitro and in vivo activity.
Communications Chemistry · Aug 14, 2025Peer-reviewedMolecular Biology