Author

Michał Biśta

ORCID 0000-0001-9237-1199Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:protein structure· 2 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Daria Gajewska· 3 shared Magdalena Sypien· 3 shared Michał WalczakiD· 3 shared Aleksandra Podkowka· 2 shared Alicja N. SkowroniD· 2 shared Anna SzlachciciD· 2 shared Daria KotlarekiD· 2 shared Igor H. WierzbickiiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Daria Gajewska

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Ligand-induced Conformational Plasticity of the CTLH E3 Ligase Receptor GID4

Daria Kotlarek, Katarzyna Dudek, Bartosz Woźniak, Martyna W. Pastok, Dmitrii V. Shishov, Sylvain Cottens, Michał Biśta, Emilia Krzywiecka, Karolina Maria Górecka, Kinga Jurczak, Tomáš Drmota, Justyna Adamczyk, Szymon Faliński, Daria Gajewska, Marta Klejnot, , Michał Walczak

This study designs high-affinity ligands for the E3 ligase GID4 to enable targeted protein degradation, identifying conformational changes and potential degrader structures, though degradation efficacy remains to be optimized.

ChemMedChem · Apr 3, 2026Peer-reviewedMolecular Biology

A Robust Crystallographic Platform for High-Throughput β-Catenin Ligand Discovery

Marta Klejnot, Alicja N. Skowron, Jaromir Szymański, Filip Ulatowski, Michał Biśta, Sylvain Cottens, Gabriela Dąbrowiecka, Daria Gajewska, Karolina Maria Górecka, Daria Kotlarek, Kinga Leszkowicz, Martyna W. Pastok, Magdalena Sypien, Igor H. Wierzbicki, Janusz Wiśniewski, Michał Walczak

This paper develops a robust crystallographic platform for discovering β-catenin ligands through optimized protein production and screening methods.

bioRxiv · Jul 13, 2025 · PreprintMolecular Biology

Expression screen of TNFR1 R347A, MyD88, IRAK4 death domains in E. coli followed by purification and biophysical characterization of TNFR1 R347A death domain

Kamil Przytulski, Aleksandra Podkowka, Tomasz Tomczyk, Daria Gajewska, Magdalena Sypien, Agnieszka Maria Jeleń, Priyanka Dahate, Anna Szlachcic, Michał Biśta, Michał Walczak

The paper optimizes expression and characterizes the stability of TNFR1 R347A, MyD88, and IRAK4 death domains in E. coli.

bioRxiv · Dec 13, 2024 · PreprintBiochemistry