The Hao-Fountain syndrome gene USP7 restricts neurotropic orthoflavivirus entry through cell intrinsic control of endosomal dynamics
Boris Bonaventure, Kyna Reyes, Marie France Martin, Heng Pan, R. Blake Richardson, Eva Bednarski, Alison W. Ashbrook, Allison Sowa, William G.M. Janssen, Oded Danziger, Anastasija Čupić, Lisa Miorin, Charles M. Rice, Jean K. Lim, Brad R. Rosenberg, , Jeffrey R. Johnson
This study identifies USP7 as a gene that restricts neurotropic orthoflavivirus entry by controlling endosomal dynamics, with mutations in USP7 increasing susceptibility to ZIKV infection.
bioRxiv · Sep 10, 2026 · PreprintMicrobiology