William G.M. Janssen

This study identifies USP7 as a gene that restricts neurotropic orthoflavivirus entry by controlling endosomal dynamics, with mutations in USP7 increasing susceptibility to ZIKV infection.

This paper shows that macroscopic and radiological perfusion metrics do not reliably predict ultrastructural preservation in brain tissue after hyperosmotic perfusion.

This study shows that deep brain stimulation remodels white matter and alters brain-wide functional connectivity in macaques, contributing to its therapeutic effects.

The paper evaluates ultrastructural preservation quality in postmortem brain tissue using EM and light microscopy to identify artifacts and assess their impact on research applications.

The paper uses MAPseq to analyze BLA neuron projections in macaques, finding that many neurons project to multiple brain regions and form structured networks.

This study shows that early-life sevoflurane exposure in rhesus monkeys leads to long-term synaptic ultrastructural changes in the hippocampus and prefrontal cortex.

The paper identifies transcriptomic changes in monocytes from GBA mutation carriers with Parkinson's disease, highlighting dysregulated pathways related to alpha-synuclein degradation and lysosomal function.

This study identifies preexisting structural and functional differences in the prelimbic-amygdala circuit that mediate vulnerability to acute social defeat stress in male mice.

This study investigates the effects of Aβ oligomers on synaptic pathology and neuroinflammation in a female rhesus monkey model of Alzheimer’s disease, finding significant synaptic loss and inflammatory responses.