Author

L. A. Miosge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Enders· 2 shared C. C. Goodnow· 2 shared J. H. Reed· 2 shared A. Closa· 1 shared B. Boast· 1 shared C. C. Oakes· 1 shared C. Goodnow· 1 shared C. M. Roots· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

A. Enders

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Author profile →

3 papers

Recent·Most cited

DOCK2-deficiency causes defects in anti-viral T cell responses and poor control of herpes simplex virus infection

K. L. Randall, I. E. A. Flesch, Y. Mei, L. A. Miosge, R. Aye, R. Aye, Z. Yu, H. Domaschenz, N. Hollett, T. Russell, T. Stefanovic, Y. C. Wong, C. C. Goodnow, E. Bertram, A. Enders, D. Tscharke

This study shows that DOCK2-deficient mice have impaired anti-viral CD8+ T cell responses and poor control of HSV-1 infection due to defects in clonal expansion and effector function.

bioRxiv · Aug 2, 2023 · PreprintImmunology

Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint

E. Masle-Farquhar, T. J. Peters, L. A. Miosge, I. A. Parish, C. Weigel, C. C. Oakes, J. H. Reed, C. Goodnow

This study identifies EGR2 and EGR3 as critical transcription factors that suppress CD21low and B1 B cell accumulation by repressing plasma cell differentiation and follicular germinal center formation.

bioRxiv · Jul 1, 2021Immunology

Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice

B. Boast, K. Helian, D. Andrews, X. Li, V. Cho, A. Closa, H. J. Sutton, J. H. Reed, H. Bergmann, C. M. Roots, M. Yabas, N. Barthel, S. A. Omari, C. Young, L. A. Miosge, , A. Enders

Reduced PAX5 function in mice leads to uncommitted B cell development and B-ALL with secondary mutations in Jak3 and Ptpn11.

bioRxiv · Jan 29, 2021 · PreprintImmunology