Author

L. A. Spruce

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

H. Fazelinia· 3 shared A. S. Naqvi· 1 shared A. Suzuki· 1 shared A. Thomas-Tikhonenko· 1 shared C. S. Abrams· 1 shared C. S. Thom· 1 shared E. M. Behrens· 1 shared F. Gonzalez· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

H. Fazelinia

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Quantitative label free mass spectrometry reveals content and signaling differences between neonatal and adult platelets

C. S. Thom, P. Davenport, H. Fazelinia, Z.-J. Liu, H. Zhang, H. Ding, J. Roof, L. A. Spruce, H. Ischiropoulos, M. Sola-Visner

This study compares the proteome and phosphoproteome of neonatal and adult platelets, identifying significant differences in protein content and phosphorylation that suggest developmental variations in immune function and activation potential.

bioRxiv · Sep 13, 2023 · PreprintCell Biology

FBXW7β isoform drives transcriptional activation of a proinflammatory TNF cluster in normal and malignant pro-B cells

S. Y. Yang, K. E. Hayer, H. Fazelinia, M. Asnani, K. L. Black, A. S. Naqvi, V. Pillai, L. A. Spruce, Y. Barash, K. S. Elenitoba-Johnson, A. Thomas-Tikhonenko

The paper identifies FBXW7β as a predominant isoform in normal and malignant pro-B cells, showing it drives a proinflammatory TNF gene cluster.

bioRxiv · Apr 24, 2022 · PreprintCell Biology

A Coxiella burnetii effector interacts with the host PAF1 complex and suppresses the innate immune response

N. Lopes Fischer, M. A. Boyer, W. P. Bradley, L. A. Spruce, H. Fazelinia, S. Shin

This study identifies CBU1314, a Coxiella burnetii effector that interacts with the host PAF1 complex to suppress innate immune responses and promote bacterial replication.

bioRxiv · Apr 20, 2022 · PreprintMicrobiology

PIKfyve deficiency in myeloid cells impairs lysosomal homeostasis in macrophages and promotes systemic inflammation in mice

S. H. Min, A. Suzuki, L. Weaver, J. Guzman, L. Zhao, F. Gonzalez, L. A. Spruce, S. H. Seeholzer, E. M. Behrens, C. S. Abrams

This study shows that PIKfyve deficiency in myeloid cells impairs lysosomal function, leading to systemic inflammation and tissue infiltration in mice.

bioRxiv · Apr 16, 2019Cell Biology