Author

H. Fazelinia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

L. A. Spruce· 3 shared J. Roof· 2 shared A. S. Naqvi· 1 shared A. Thomas-Tikhonenko· 1 shared A. W. Paton· 1 shared C. S. Thom· 1 shared C.-C. A. Hu· 1 shared C.-H. A. Tang· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCell Biology

L. A. Spruce

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

An exploration of mechanisms underlying Desemzia incerta colonization resistance to methicillin-resistant Staphylococcus aureus on the skin

M. Wei, S. A. B. Knight, H. Fazelinia, L. Spruce, J. Roof, E. W. Chu, J. Walsh, L. Flowers, D. Y. Kim, J. Zhu, E. A. Grice

This study identifies Desemzia incerta as a skin commensal that reduces MRSA colonization through secreted antimicrobial proteins and decreased biofilm formation in a murine model.

bioRxiv · Oct 11, 2023 · PreprintMicrobiology

Quantitative label free mass spectrometry reveals content and signaling differences between neonatal and adult platelets

C. S. Thom, P. Davenport, H. Fazelinia, Z.-J. Liu, H. Zhang, H. Ding, J. Roof, L. A. Spruce, H. Ischiropoulos, M. Sola-Visner

This study compares the proteome and phosphoproteome of neonatal and adult platelets, identifying significant differences in protein content and phosphorylation that suggest developmental variations in immune function and activation potential.

bioRxiv · Sep 13, 2023 · PreprintCell Biology

FBXW7β isoform drives transcriptional activation of a proinflammatory TNF cluster in normal and malignant pro-B cells

S. Y. Yang, K. E. Hayer, H. Fazelinia, M. Asnani, K. L. Black, A. S. Naqvi, V. Pillai, L. A. Spruce, Y. Barash, K. S. Elenitoba-Johnson, A. Thomas-Tikhonenko

The paper identifies FBXW7β as a predominant isoform in normal and malignant pro-B cells, showing it drives a proinflammatory TNF gene cluster.

bioRxiv · Apr 24, 2022 · PreprintCell Biology

A Coxiella burnetii effector interacts with the host PAF1 complex and suppresses the innate immune response

N. Lopes Fischer, M. A. Boyer, W. P. Bradley, L. A. Spruce, H. Fazelinia, S. Shin

This study identifies CBU1314, a Coxiella burnetii effector that interacts with the host PAF1 complex to suppress innate immune responses and promote bacterial replication.

bioRxiv · Apr 20, 2022 · PreprintMicrobiology

The interdomain helix between the kinase and RNase domains of IRE1α transmits the conformational change that underlies ER stress-induced activation.

D. Ricci, S. Tutton, I. Marrocco, M. Ying, D. Blumenthal, D. Eletto, J. Vargas, S. Boyle, H. Fazelinia, J. C. Paton, A. W. Paton, C.-H. A. Tang, C.-C. A. Hu, T. Gidalevitz, Y. Argon

This study identifies the interdomain helix between IRE1α kinase and RNase domains as critical for transmitting conformational changes during ER stress, revealing its role in regulating oligomerization, RNase activity, and kinase function.

bioRxiv · Jan 14, 2020 · PreprintBiochemistry