Author

L. Barfod

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:plant (other)· 1 Assay:proteomics· 1 Organism:rat· 1 Assay:structural biology· 1

Frequent Co-Authors

I. Campeotto· 2 shared S. J. Draper· 2 shared V. Kotraiah· 2 shared A. D. Douglas· 1 shared A. J. Birkett· 1 shared A. M. Frank· 1 shared A. M. Lias· 1 shared A. P. Snijders· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiophysics

I. Campeotto

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex

B. G. Williams, L. D. W. King, D. Pulido, D. Quinker, A. M. Lias, S. E. Silk, R. J. Ragotte, H. Davies, J. R. Barrett, K. McHugh, C. A. Rigby, D. G. W. Alanine, L. Barfod, M. W. Shea, L. A. Cowley, , S. J. Draper

This paper develops a combination malaria vaccine targeting the RCR-complex by fusing epitopes from RIPR to CyRPA, improving in vitro growth inhibition compared to RH5.1 alone.

Nature Communications · Jun 7, 2024Peer-reviewedImmunology

Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP and its antibody response characterisation

S. Batra, F. Olmo, T. J. Ragan, A. M. Frank, M. Kaplan, C. Lancey, M. Assadipapari, C. Ying, W. B. Struwe, E. Hesketh, J. M. Kelly, L. Barfod, I. Campeotto

This study determines the 3D structures of TcPOP in open and closed conformations using cryo-EM and evaluates its immunogenicity through antibody responses in mice.

bioRxiv · Mar 26, 2024 · PreprintBiophysics

Structure of the cysteine-rich domain of Plasmodium falciparum P113 identifies the location of the RH5 binding site

I. Campeotto, F. Galaway, S. Mehmood, L. Barfod, D. Quinkert, V. Kotraiah, T. W. Phares, K. E. Wright, A. P. Snijders, S. J. Draper, M. Higgins, G. J. Wright

The paper determines the structure of the RH5-binding region of P113 and identifies the binding site, providing insights for malaria vaccine development.

mBio · Oct 27, 2020Peer-reviewedMicrobiology