Author

A. D. Douglas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Organism:rat· 1 Assay:structural biology· 1

Frequent Co-Authors

R. R. Segireddy· 2 shared A. A. Walters· 1 shared A. Berg· 1 shared A. J. Birkett· 1 shared A. J. Ritchie· 1 shared A. M. Lias· 1 shared A. R. Noe· 1 shared A. V. Hill· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

R. R. Segireddy

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex

B. G. Williams, L. D. W. King, D. Pulido, D. Quinker, A. M. Lias, S. E. Silk, R. J. Ragotte, H. Davies, J. R. Barrett, K. McHugh, C. A. Rigby, D. G. W. Alanine, L. Barfod, M. W. Shea, L. A. Cowley, , S. J. Draper

This paper develops a combination malaria vaccine targeting the RCR-complex by fusing epitopes from RIPR to CyRPA, improving in vitro growth inhibition compared to RH5.1 alone.

Nature Communications · Jun 7, 2024Peer-reviewedImmunology

Structure of trimeric pre-fusion rabies virus glycoprotein in complex with two protective antibodies

W. M. Ng, S. Fedosyuk, S. English, G. Augusto, A. Berg, L. Thorley, R. R. Segireddy, T. A. Bowden, A. D. Douglas

The paper reports the structure of pre-fusion rabies virus glycoprotein complexed with two protective antibodies, showing how they stabilize the protein and provide insights for vaccine design.

bioRxiv · Feb 28, 2022Microbiology

A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host-pathogen interactions

R. R. Segireddy, K. Dundas, J. Knoeckel, F. Galaway, L. Wood, G. J. Wright, A. D. Douglas

The paper identifies novel host-pathogen interactions between Plasmodium falciparum sporozoite proteins and human hepatocyte surface receptors using a high-throughput screening assay.

bioRxiv · Feb 2, 2020Microbiology

Characterisation of factors contributing to the performance of nonwoven fibrous matrices as substrates for adenovirus vectored vaccine stabilisation

P. Dulal, A. A. Walters, N. Hawkins, T. D. Claridge, K. Kowal, S. Neill, S. J. Russell, A. J. Ritchie, R. Ashfield, A. V. Hill, A. D. Douglas

The paper investigates fibrous matrices for adenovirus vaccine stabilisation, identifies polyvinyl alcohol as a key stabilising component, and develops a custom matrix for clinical translation.

bioRxiv · Jan 31, 2020Pharmacology & Toxicology