Author
L. Broadbent
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2018-2021 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 28 mutual co-author links7 papers
Recent·Most cited
An Endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells
L. Broadbent, C. G. G. Bamford, G. Lopez Campos, S. Manzoor, D. Courtney, A. Ali, O. Touzelet, C. McCaughey, K. Mills, U. Power
The paper shows that an endogenous IFNλ pathway provides resistance to SARS-CoV-2 in airway epithelial cells, with high baseline IFNλ correlating with resistance.
bioRxiv · Aug 17, 2021Immunology
Collaboration Between Host and Viral Factors Shape SARS-CoV-2 Evolution
C. G. G. Bamford, L. Broadbent, E. Aranday Cortes, M. McCabe, J. McKenna, D. Courtney, O. Touzelet, A. Ali, G. Roberts, G. Lopez Campos, D. Simpson, C. McCaughey, D. Fairley, K. Mills, U. F. Power, The Breathing Together Consortium
This study investigates how viral and host factors influence SARS-CoV-2 evolution in vitro, identifying genetic changes and their impact on viral fitness in different cell types.
bioRxiv · Jul 16, 2021 · PreprintMicrobiology
Comparative therapeutic potential of ALX-0171 and palivizumab against RSV clinical isolate infection of well-differentiated primary pediatric bronchial epithelial cell cultures
L. Broadbent, H. Guo Parke, L. J. Ferguson, A. Miller, M. D. Shields, L. Detalle, U. F. Power
This study compares the therapeutic efficacy of ALX-0171 and palivizumab against RSV infection in a human bronchial epithelial cell model, showing ALX-0171 is more potent at neutralizing virus but less effective at reducing viral genomic copies.
Antimicrobial Agents and Chemotherapy · Jan 27, 2020Peer-reviewedMicrobiology
Comparative primary paediatric nasal epithelial cell culture differentiation and RSV-induced cytopathogenesis following culture in two commercial media.
L. Broadbent, S. Manzoor, M. Zarcone, J. Barabas, M. Shields, S. Saglani, C. M. Lloyd, A. Bush, A. Custovic, P. Ghazal, M. Gore, B. Marsland, G. Roberts, J. Schwarze, S. Turner, U. F. Power
This study compares two commercial media for culturing primary nasal epithelial cells and evaluates their impact on cell morphology, physiology, and RSV infection outcomes.
bioRxiv · Jan 13, 2020Cell Biology
The Role of Toll-like receptor 4 in respiratory syncytial virus replication, interferon lambda 1 induction, and chemokine responses.
L. Broadbent, J. D. Coey, M. D. Shields, U. F. Power
This study investigates the role of TLR4 in RSV infection, IFN-λ1 induction, and chemokine responses using a human bronchial epithelial cell model, finding that TLR4 signaling through NF-κB and p38 MAPK mediates these effects.
bioRxiv · Aug 30, 2018 · PreprintMicrobiology
Characterisation of morphological differences in well-differentiated nasal epithelial cell cultures from preterm and term infants at birth and one-year.
H. Groves, H. Guo-Parke, L. Broadbent, M. Shields, U. Power
The paper characterizes morphological differences in nasal epithelial cell cultures from preterm and term infants at birth and one-year, finding that newborn cultures take longer to differentiate and have more goblet cells.
bioRxiv · Jul 16, 2018Immunology