Author

D. Courtney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

A. Ali· 2 shared C. G. G. Bamford· 2 shared C. Isel· 2 shared C. McCaughey· 2 shared G. Lopez Campos· 2 shared K. Mills· 2 shared L. Broadbent· 2 shared N. Naffakh· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

A. Ali

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The RBPome of influenza A virus mRNA reveals a role for TDP-43 in viral replication

M. Dupont, T. Krischuns, Q. Giai Gianetto, S. Paisant, S. Bonazza, J.-B. Brault, T. Douche, J. I. Perez-Perri, M. W. Hentze, S. Cusack, M. Matondo, C. Isel, D. Courtney, N. Naffakh

The paper identifies RBPs associated with influenza A virus NP mRNA and shows TDP-43's role in viral replication through mRNA binding and polymerase interactions.

bioRxiv · Mar 21, 2023 · PreprintMicrobiology

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

K.-Y. Chen, T. Krischuns, L. Ortega Varga, E. Harigua-Souiai, S. Paisant, A. Zettor, J. Chiaravalli, D. Courtney, A. O'Brien, S. Baker, C. Isel, F. Agou, Y. Jacob, A. Blondel, N. Naffakh

The paper develops a sensitive cell-based luciferase assay for high-throughput screening of SARS-CoV-2 nsp5/3CLpro inhibitors and identifies four effective compounds.

bioRxiv · Dec 18, 2021Microbiology

An Endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells

L. Broadbent, C. G. G. Bamford, G. Lopez Campos, S. Manzoor, D. Courtney, A. Ali, O. Touzelet, C. McCaughey, K. Mills, U. Power

The paper shows that an endogenous IFNλ pathway provides resistance to SARS-CoV-2 in airway epithelial cells, with high baseline IFNλ correlating with resistance.

bioRxiv · Aug 17, 2021Immunology

Collaboration Between Host and Viral Factors Shape SARS-CoV-2 Evolution

C. G. G. Bamford, L. Broadbent, E. Aranday Cortes, M. McCabe, J. McKenna, D. Courtney, O. Touzelet, A. Ali, G. Roberts, G. Lopez Campos, D. Simpson, C. McCaughey, D. Fairley, K. Mills, U. F. Power, The Breathing Together Consortium

This study investigates how viral and host factors influence SARS-CoV-2 evolution in vitro, identifying genetic changes and their impact on viral fitness in different cell types.

bioRxiv · Jul 16, 2021 · PreprintMicrobiology

Extensive epitranscriptomic methylation of A and C residues on murine leukemia virus transcripts enhances viral gene expression

D. Courtney, A. Chalem, H. P. Bogerd, B. A. Law, E. M. Kennedy, C. L. Holley, B. R. Cullen

This study shows that murine leukemia virus (MLV) transcripts have high levels of m6A, m5C, and Nm modifications, which enhance viral replication and gene expression.

bioRxiv · Mar 28, 2019Microbiology