Author

M. D. Amaral

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:organoid / primary culture· 2 Research Focus:cell type annotation· 1 Assay:protein sequence· 1

Frequent Co-Authors

C. K. van der Ent· 2 shared G. D. Amatngalim· 2 shared J. M. Beekman· 2 shared L. W. Rodenburg· 2 shared A. C. Da Paula· 1 shared B. L. Aalbers· 1 shared C. F. J. van Hugten· 1 shared C. M. Farinha· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCell Biology

C. K. van der Ent

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Drug repurposing for Cystic Fibrosis: identification of drugs that induce CFTR-independent fluid secretion in nasal organoids

L. W. Rodenburg, L. Delpiano, V. Railean, R. Centeio, M. C. Pinto, S. M. A. Smits, I. S. van der Windt, C. F. J. van Hugten, S. F. B. van Beuningen, R. N. P. Rodenburg, C. K. van der Ent, M. D. Amaral, K. Kunzelmann, M. A. Gray, J. M. Beekman, G. D. Amatngalim

This study identifies 12 FDA-approved drugs that induce CFTR-independent fluid secretion in nasal organoids, offering potential treatment for CF patients unresponsive to CFTR modulators.

bioRxiv · Sep 23, 2022Cell Biology

Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia

G. D. Amatngalim, L. W. Rodenburg, B. L. Aalbers, H. H. M. Raeven, E. M. Aarts, I. A. L. Silva, W. Nijenhuis, S. Vrendenbarg, E. Kruisselbrink, J. Brunsveld, C. M. van Drunen, S. Michel, K. M. de Winter-de Groot, H. G. Heijerman, L. C. Kapitein, , J. M. Beekman

This study develops an improved method to measure CFTR drug responses in nasal airway organoids derived from 2D differentiated epithelial cells.

bioRxiv · Jul 20, 2021Cell Biology

Full Rescue of F508del-CFTR Processing and Function by CFTR Modulators can be Achieved by Removal of Two Unique Regulatory Regions

I. Uliyakina, A. C. Da Paula, S. C. Afonso, M. J. Lobo, V. Felicio, H. M. Botelho, C. M. Farinha, M. D. Amaral

This paper investigates how removing regulatory regions in CFTR affects F508del-CFTR rescue by modulators, finding that RI impacts processing while RE affects stability and function.

bioRxiv · May 11, 2018Biochemistry