M. Hofmann

CLEC18A interacts with sulfated GAGs and controls clear cell renal cell carcinoma progression

This study identifies CLEC18A as a regulator of clear cell renal cell carcinoma progression by interacting with sulfated GAGs and shows its expression is linked to improved patient survival.

Proteome dynamics reveal Leiomodin 1 as a key regulator of myogenic differentiation

The paper identifies LMOD1 as a key regulator of myogenic differentiation through proteome dynamics and functional studies.

Optogenetic control of pheromone gradients and mating behavior in budding yeast

The paper uses optogenetic tools to control pheromone gradients in budding yeast, enabling spatial regulation of mating behavior and cell fusion.

Efficient formation and maintenance of humoral and CD4 T cell immunity targeting the viral capsid in acute-resolving hepatitis E infection

The paper longitudinally characterizes HEV-specific CD4 T cells and neutralizing antibodies targeting nHEV and eHEV in acute and resolved HEV infection, finding capsid-specific immunity dominates and correlates with nAb responses.

Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning

This study investigates how HCMV US10 protein regulates HLA-I genotype and surface expression, revealing its multimodal effects on different HLA-I allotypes.

Parity modulates impact of BMI and Gestational Weight Gain on gut microbiota in human pregnancy

The paper examines how parity affects the relationship between pre-pregnancy BMI, gestational weight gain, and gut microbiota changes during pregnancy and in infants.

ProteasomeID: quantitative mapping of proteasome interactomes and substrates for in vitro and in vivo studies

This study develops a method to quantify proteasome interactomes and substrates in vivo using biotin ligases and a new mouse model, identifying novel interactors and substrates.

Structural and functional insight into the plant unique multimodular triphosphosphate tunnel metalloenzymes of Arabidopsis thaliana

This study characterizes the structural and functional properties of two multimodular triphosphosphate tunnel metalloenzymes in Arabidopsis thaliana, revealing their roles in developmental transitions.

Adaptive subsets limit the anti-tumoral NK-cell activity in Hepatocellular Carcinoma

This study shows that adaptive NK cells have reduced anti-tumoral activity in HCC patients, particularly in those with HBV infection, and are expanded in such cases.

Ex vivo detection of SARS-CoV-2-specific CD8+ T cells: rapid induction, prolonged contraction, and formation of functional memory

This study identifies SARS-CoV-2-specific CD8+ T-cell responses, showing their rapid induction, prolonged contraction, and functional memory formation compared to antibody responses.

One score to rule them all: severity assessment in laboratory mice

This paper develops a severity assessment score for laboratory mice using physiological and behavioral data to evaluate postoperative recovery and model-specific severity levels.