Author

L. E. Clark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. Coscia· 2 shared J. Abraham· 2 shared J. Pan· 2 shared S. A. Clark· 2 shared A. D. Attie· 1 shared A. Griffiths· 1 shared B. S. Yandell· 1 shared C. Emfinger· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

A. Coscia

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural basis for VLDLR recognition by eastern equine encephalitis virus

P. Yang, W. Li, X. Fan, J. Pan, C. J. Mann, H. Varnum, L. E. Clark, S. A. Clark, A. Coscia, K. N. Smith, V. Brusic, J. Abraham

This study determines the structures of EEEV and SFV spike glycoproteins bound to VLDLR, revealing distinct binding modes that explain how different alphaviruses use the same receptor.

bioRxiv · Nov 14, 2023Microbiology

Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations

C. Emfinger, L. E. Clark, B. S. Yandell, K. L. Schueler, S. Simonett, D. S. Stapleton, K. Mitok, M. J. Merrins, M. P. Keller, A. D. Attie

The paper identifies novel regulators of islet Ca2+ oscillations and insulin secretion by integrating genetic variation, Ca2+ dynamics, and protein abundance in mouse islets with human GWAS data.

bioRxiv · Nov 26, 2022 · PreprintBiochemistry

Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2

S. A. Clark, L. E. Clark, J. Pan, A. Coscia, L. G. A. McKay, S. Shankar, R. I. Johnson, A. Griffiths, J. Abraham

The paper identifies germline-biased neutralizing antibodies against SARS-CoV-2 and shows that affinity gains do not always correlate with neutralization potency.

bioRxiv · Nov 13, 2020Microbiology