Disulfide disruption reverses mucus dysfunction in allergic airway disease
L. E. Morgan, S. K. Shenoy, D. Raclawska, N. A. Emezienna, V. L. Richardson, N. Hara, A. Q. Harder, H. M. El-Batal, C. M. Magin, D. E. G. Villalon, G. Duncan, J. S. Hanes, J. S. Suk, D. J. Thornton, F. Holguin, , C. M. Evans
This study shows that reducing disulfide bonds in mucins reverses mucus dysfunction in asthma by improving mucociliary clearance and reducing airway hyperreactivity.
bioRxiv · Sep 14, 2019Physiology