Author

F. Holguin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

C. M. Evans· 2 shared L. E. Morgan· 2 shared N. Hara· 2 shared W. J. Janssen· 2 shared A. Kato· 1 shared A. M. Jaramillo· 1 shared A. Q. Harder· 1 shared C. M. Magin· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPhysiology

C. M. Evans

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Author profile →

2 papers

Recent·Most cited

Requirement for Fucosyltransferase 2 in Allergic Airway Hyperreactivity and Mucus Obstruction

N. Hara, D. S. Raclawska, L. E. Morgan, J. C. Needell, L. Dao, A. Kato, A. M. Jaramillo, P. S. Hume, F. Holguin, W. J. Janssen, E. K. Vladar, C. M. Evans

This study identifies fucosyltransferase 2 (Fut2) as essential for mucin fucosylation, which contributes to allergic airway hyperreactivity and mucus obstruction in mice.

bioRxiv · May 10, 2024Physiology

Disulfide disruption reverses mucus dysfunction in allergic airway disease

L. E. Morgan, S. K. Shenoy, D. Raclawska, N. A. Emezienna, V. L. Richardson, N. Hara, A. Q. Harder, H. M. El-Batal, C. M. Magin, D. E. G. Villalon, G. Duncan, J. S. Hanes, J. S. Suk, D. J. Thornton, F. Holguin, , C. M. Evans

This study shows that reducing disulfide bonds in mucins reverses mucus dysfunction in asthma by improving mucociliary clearance and reducing airway hyperreactivity.

bioRxiv · Sep 14, 2019Physiology