Author

L. Frei

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

S. T. Reddy· 3 shared J. M. Taft· 2 shared A. Agrafiotis· 1 shared A. G. Lujan Hernandez· 1 shared A. Gietl· 1 shared A. Iwasaki· 1 shared A. Mallone· 1 shared A. Mariotte· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersImmunology

S. T. Reddy

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4 papers

Recent·Most cited

Altered T cell reactivity to β-amyloid-related antigens in early Alzheimer's disease

C. Rickenbach, A. Mallone, L. Haeusle, L. Frei, S. Seiter, C. Sparano, T. Kirabali, K. Blennow, H. Zetterberg, M. T. Ferretti, L. Kulic, C. Hock, R. M. Nitsch, V. Treyer, A. Gietl, C. Gericke

The paper examines immune changes in early Alzheimer's disease stages, finding altered T cell reactivity to β-amyloid-related antigens in preclinical AD and MCI.

bioRxiv · Jun 4, 2024 · PreprintImmunology

Deep learning-guided selection of antibody therapies with enhanced resistance to current and prospective SARS-CoV-2 Omicron variants

L. Frei, B. Gao, J. Han, J. M. Taft, E. B. Irvine, C. R. Weber, R. Kumar, B. Eisinger, S. T. Reddy

This study uses deep learning to identify antibodies resistant to SARS-CoV-2 Omicron variants by predicting their binding and escape from mutations.

bioRxiv · Oct 9, 2023 · PreprintImmunology

Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity

D. Shlesinger, K.-L. Hong, G. Shammas, N. Page, I. Sandu, A. Agrafiotis, V. Kreiner, N. Fonta, I. Vincenti, I. Wagner, M. Piccinno, A. Mariotte, B. Klimek, R. Dizerens, M. Manero-Carranza, , A. Yermanos

The paper profiles clonal selection of B and T cells in murine models of infection and autoimmunity using single-cell sequencing, linking repertoire features to cell phenotypes.

bioRxiv · Feb 7, 2022Immunology

A synthetic bispecific antibody capable of neutralizing SARS-CoV-2 Delta and Omicron

T. Z. Yuan, C. Lucas, V. S. Monteiro, A. Iwasaki, M. L. Yang, H. F. Nepita, A. G. Lujan Hernandez, J. M. Taft, L. Frei, S. T. Reddy, C. Weber, K. P. Malobisky, R. Mesquita, A. Sato

This paper describes a synthetic bispecific antibody that neutralizes SARS-CoV-2 Delta and Omicron variants with picomolar affinity.

bioRxiv · Jan 4, 2022 · PreprintImmunology