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Interleukin-33 from oligodendrocytes sustains effector differentiation of tissue-resident CD8+ T cells and is a druggable target in CNS autoimmune disease

This study identifies IL-33 from oligodendrocytes as a key regulator of self-reactive CD8+ T cell differentiation in CNS autoimmunity and shows its potential as a therapeutic target.

Distribution models predict climate-related range alteration or extinction of eleven threatened tropical rainforest trees in the Western Ghats

The paper models climate impacts on 11 threatened tropical tree species in the Western Ghats, predicting range reductions or extinctions under future climate scenarios.

Chronic disturbance of moist tropical forests favours deciduous over evergreen tree communities across a climate gradient in the Western Ghats

This study shows that chronic disturbance in tropical forests favors deciduous over evergreen tree communities, especially under water stress, in the Western Ghats.

Frugivory and seed predation of fishtail palm (Caryota mitis Lour.) on the remote oceanic island of Narcondam, India

The paper examines seed dispersal and predation of Caryota mitis on Narcondam Island, finding that the endemic hornbill is the sole disperser and the invasive rodent is the sole predator, leading to low seed survival.

Range restricted old and young lineages show the southern Western Ghats to be both museum and cradle of diversity for woody plants

The paper examines the southern Western Ghats as both a museum and cradle of woody plant evolutionary diversity using phylogenetic and distribution analyses.

Persistent virus-specific and clonally expanded antibody secreting cells respond to induced self antigen in the CNS

The paper identifies virus-specific, clonally expanded antibody-secreting cells in the CNS that persist and respond to induced self-antigen, with parallels in multiple sclerosis patients.

Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity

The paper profiles clonal selection of B and T cells in murine models of infection and autoimmunity using single-cell sequencing, linking repertoire features to cell phenotypes.

Brain endothelial antigen presentation detains CD8+ T cells at the blood-brain barrier leading to its breakdown

The paper shows that brain endothelial antigen presentation inhibits CD8+ T-cell movement and causes BBB breakdown in MS.

Waning grasslands: a quantitative temporal evaluation of the grassland habitats across human-dominated upper Gangetic Plains, north India

The paper quantitatively assesses the decline of grassland habitats in the upper Gangetic Plains over 30 years, finding a 57% reduction mainly due to conversion to croplands.

Cold Exposure Protects from Neuroinflammation Through Immunologic Reprogramming

The paper shows cold exposure reduces neuroinflammation by altering monocyte function and T cell priming in mouse models of autoimmune encephalomyelitis.

Large frugivores matter more on an island: insights from island-mainland comparison of plant-frugivore communities

The paper compares plant-frugivore communities on an island and mainland, finding the island community more asymmetric and nested, with figs and the Narcondam Hornbill playing central roles.

Salivary gland macrophages assist tissue-resident CD8+ T cell immune surveillance

The paper uses imaging to show salivary gland TRM use unique motility and tissue macrophages assist in their surveillance.

In vivo function of the lipid raft protein Flotillin 1 during CD8+ T cell-mediated host surveillance

This study investigates the role of Flotillin 1 in CD8+ T cell migration and immune responses, finding minimal impact on cell behavior under physiological conditions.