Author

L. H. Sigua

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. Qi· 2 shared A. J. Stein· 1 shared B. H. Liu· 1 shared B. J. Groendyke· 1 shared B. L. Ebert· 1 shared B. Sandoval· 1 shared C. Budjan· 1 shared C. Gao· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

J. Qi

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Author profile →

2 papers

Recent·Most cited

SALLB not targeted by IMiDs is important for maintenance of liver cancer cells

K. A. L. Vu, S. Moein, K. Kumari, B. H. Liu, C. Gao, M. Liu, M.-Y. Dai, Z. Liu, F. Li, J. P. Tang, D. Maddalo, D. S. Auld, D. E. Casalena, X. Tian, M. A. Bassal, , L. Chai

The paper identifies a compound that degrades both SALL4 isoforms, overcoming IMiD limitations in liver cancer treatment.

bioRxiv · Jul 7, 2023 · PreprintCancer Biology

Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders

Y.-D. Li, M. W. Ma, M. M. Hassan, M. Hunkeler, M. Teng, K. Puvar, R. Lumpkin, B. Sandoval, C. Y. Jin, S. B. Ficarro, M. Y. Wang, S. Xu, B. J. Groendyke, L. H. Sigua, I. Tavares, , B. L. Ebert

This paper describes a new mechanism for molecular glue degraders called template-assisted covalent modification, showing how BRD4 degraders recruit CUL4DCAF16 to degrade BRD4.

bioRxiv · Feb 14, 2023Biochemistry