Author

B. J. Groendyke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

E. S. Fischer· 3 shared B. L. Ebert· 2 shared B. Sandoval· 2 shared C. Y. Jin· 2 shared J. Qi· 2 shared K. A. Donovan· 2 shared K. Puvar· 2 shared M. M. Hassan· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPharmacology & Toxicology

E. S. Fischer

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3 papers

Recent·Most cited

Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues

M. M. Hassan, Y.-D. Li, M. W. Ma, M. Teng, W. S. Byun, K. Puvar, R. Lumpkin, B. Sandoval, J. C. Rutter, C. Y. Jin, M. Y. Wang, S. Xu, A. M. Schmoker, H. Cheong, B. J. Groendyke, , N. Gray

This study evaluates how electrophilic modifications to JQ1 affect DCAF16 trans-labeling and BRD4 degradation, showing a correlation between warhead exposure and degradation efficiency.

bioRxiv · Oct 7, 2023 · PreprintPharmacology & Toxicology

Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders

Y.-D. Li, M. W. Ma, M. M. Hassan, M. Hunkeler, M. Teng, K. Puvar, R. Lumpkin, B. Sandoval, C. Y. Jin, S. B. Ficarro, M. Y. Wang, S. Xu, B. J. Groendyke, L. H. Sigua, I. Tavares, , B. L. Ebert

This paper describes a new mechanism for molecular glue degraders called template-assisted covalent modification, showing how BRD4 degraders recruit CUL4DCAF16 to degrade BRD4.

bioRxiv · Feb 14, 2023Biochemistry

Development and utility of a PAK1-selective degrader

H.-Y. Chow, S. Karchugina, B. J. Groendyke, S. Toenjes, J. Hatcher, K. A. Donovan, E. S. Fischer, G. Abalakov, B. Faezov, R. L. Dunbrack, N. S. Gray, J. Chernoff

This study develops a PAK1-selective degrader, BJG-05-039, which shows enhanced anti-proliferative effects compared to the parent inhibitor NVS-PAK1-1 in PAK1-dependent cell lines.

bioRxiv · May 12, 2022Cancer Biology