Author

R. Lumpkin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

E. S. Fischer· 3 shared B. J. Groendyke· 2 shared B. L. Ebert· 2 shared B. Sandoval· 2 shared C. Y. Jin· 2 shared J. Qi· 2 shared K. A. Donovan· 2 shared K. Puvar· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

E. S. Fischer

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues

M. M. Hassan, Y.-D. Li, M. W. Ma, M. Teng, W. S. Byun, K. Puvar, R. Lumpkin, B. Sandoval, J. C. Rutter, C. Y. Jin, M. Y. Wang, S. Xu, A. M. Schmoker, H. Cheong, B. J. Groendyke, , N. Gray

This study evaluates how electrophilic modifications to JQ1 affect DCAF16 trans-labeling and BRD4 degradation, showing a correlation between warhead exposure and degradation efficiency.

bioRxiv · Oct 7, 2023 · PreprintPharmacology & Toxicology

Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders

Y.-D. Li, M. W. Ma, M. M. Hassan, M. Hunkeler, M. Teng, K. Puvar, R. Lumpkin, B. Sandoval, C. Y. Jin, S. B. Ficarro, M. Y. Wang, S. Xu, B. J. Groendyke, L. H. Sigua, I. Tavares, , B. L. Ebert

This paper describes a new mechanism for molecular glue degraders called template-assisted covalent modification, showing how BRD4 degraders recruit CUL4DCAF16 to degrade BRD4.

bioRxiv · Feb 14, 2023Biochemistry

Targeted degradation of the oncogenic phosphatase SHP2

V. Vemulapalli, K. A. Donovan, T. Seegar, J. M. Rogers, M. Bae, R. Lumpkin, R. Cao, M. Henke, E. S. Fischer, G. Cuny, S. C. Blacklow

This paper develops a SHP2 PROTAC that degrades SHP2 in leukemic cells, inhibits MAPK signaling, and suppresses cancer growth.

bioRxiv · Jun 2, 2021 · PreprintBiochemistry