Author

L. Jostins-Dean

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Filer· 1 shared A. Jainarayanan· 1 shared A. Jonsson· 1 shared A. L. Corbin· 1 shared A. Wagner· 1 shared A. Walsh· 1 shared A.-I. Voda· 1 shared B. M. Kessler· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperImmunology

A. Filer

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Author profile →

2 papers

Recent·Most cited

A longitudinal single-cell therapeutic atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

T. Thomas, C. Rich-Griffin, M. Pohin, M. Friedrich, D. Aschenbrenner, J. Pakpoor, A. Jainarayanan, A.-I. Voda, R. Sanches Peres, E. Nee, D. Sathananthan, D. Kotliar, J. Turner, S. Nayar, F. Zhang, , C. Buckley

This study creates a therapeutic atlas of anti-TNF treatment in IBD, showing disease- and therapy-specific cellular changes and identifying IFN signalling as a potential target for JAK inhibition.

bioRxiv · May 5, 2023Immunology

PYK2 controls intestinal inflammation via activation of IRF5 in macrophages

G. Ryzhakov, H. Almuttaqi, A. L. Corbin, T. Khoyratty, D. Berthold, S. Bullers, H. L. Eames, Z. Ai, S. Bonham, R. Fischer, L. Jostins-Dean, S. P. L. Travis, B. M. Kessler, I. A. Udalova

This study identifies PYK2 as a key regulator of intestinal inflammation by activating IRF5 in macrophages, showing reduced inflammation in colitis models and human ulcerative colitis biopsies.

bioRxiv · May 24, 2020 · PreprintImmunology