Author

L. K. Estes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:transcription & RNA processing· 1 Research Focus:variant effect prediction· 1 Organism:virus· 1

Frequent Co-Authors

D. H. Walker· 2 shared V. D. Menachery· 2 shared A. L. Greninger· 1 shared A. L. Morgan· 1 shared A. L. Routh· 1 shared A. M. McLeland· 1 shared A. Pekosz· 1 shared B. A. Ballif· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

D. H. Walker

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation

H. C. Kubinski, H. W. Despres, B. A. Johnson, M. M. Schmidt, S. A. Jaffrani, M. G. Mills, K. Lokugamage, C. M. Dumas, D. J. Shirley, L. K. Estes, A. Pekosz, J. W. Crothers, P. Roychoudhury, A. L. Greninger, K. R. Jerome, , E. A. Bruce

The paper identifies a mutation in the SARS-CoV-2 nucleocapsid protein that enhances viral infection by promoting dimer formation and altering virion structure.

bioRxiv · Mar 8, 2024 · PreprintMicrobiology

Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection

M. N. Vu, R. E. Alvarado, D. R. Morris, K. G. Lokugamage, Y. Zhou, A. L. Morgan, L. K. Estes, A. M. McLeland, C. Schindewolf, J. A. Plante, Y. P. Ahearn, W. M. Meyers, J. T. Murray, S. Weaver, D. H. Walker, , V. D. Menachery

This study identifies the N679K mutation in Omicron variants as reducing spike protein expression and attenuating SARS-CoV-2 infection, while showing a replication advantage in the upper airway.

bioRxiv · Apr 17, 2023Microbiology