Author

E. A. Bruce

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

A. L. Greninger· 2 shared D. J. Shirley· 2 shared J. W. Botten· 2 shared J. W. Crothers· 2 shared K. R. Jerome· 2 shared M. M. Schmidt· 2 shared M. S. Ladinsky· 2 shared A. Finzi· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

A. L. Greninger

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation

H. C. Kubinski, H. W. Despres, B. A. Johnson, M. M. Schmidt, S. A. Jaffrani, M. G. Mills, K. Lokugamage, C. M. Dumas, D. J. Shirley, L. K. Estes, A. Pekosz, J. W. Crothers, P. Roychoudhury, A. L. Greninger, K. R. Jerome, , E. A. Bruce

The paper identifies a mutation in the SARS-CoV-2 nucleocapsid protein that enhances viral infection by promoting dimer formation and altering virion structure.

bioRxiv · Mar 8, 2024 · PreprintMicrobiology

Live imaging of SARS-CoV-2 infection in mice reveals neutralizing antibodies require Fc function for optimal efficacy

I. Ullah, J. Prevost, M. S. Ladinsky, H. Stone, M. Lu, S. P. Anand, G. Beaudoin-Bussieres, K. Symmes, M. Benlarbi, S. Ding, R. Gasser, C. Fink, Y. Chen, A. Tauzin, G. Goyette, , P. D. Uchil

This study uses live imaging to show that neutralizing antibodies against SARS-CoV-2 need both Fab and Fc functions to effectively prevent and resolve infection in mice.

bioRxiv · Mar 22, 2021Immunology

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro

N. Drayman, K. A. Jones, S.-A. Azizi, H. M. Froggatt, K. Tan, N. Ivanova Maltseva, S. Chen, V. Nicolaescu, S. Dvorkin, K. Furlong, R. S. Kathayat, M. R. Firpo, V. Mastrodomenico, E. A. Bruce, M. M. Schmidt, , S. Tay

The paper screens 1,900 drugs to find inhibitors of SARS-CoV-2 replication, identifies masitinib as a 3CLpro inhibitor effective in vitro, and shows its broad anti-viral activity.

bioRxiv · Aug 31, 2020Microbiology

DIRECT RT-qPCR DETECTION OF SARS-CoV-2 RNA FROM PATIENT NASOPHARYNGEAL SWABS WITHOUT AN RNA EXTRACTION STEP

E. A. Bruce, M.-L. Huang, G. A. Perchetti, S. Tighe, J. J. Hoffman, P. Laaguiby, D. L. Gerrard, A. Nalla, Y. Wei, A. L. Greninger, S. A. Diehl, D. J. Shirley, D. G. B. Leonard, C. D. Huston, B. D. Kirkpatrick, , J. W. Botten

This paper tests a direct RT-qPCR method for detecting SARS-CoV-2 RNA in nasal swabs without RNA extraction, achieving 92% accuracy on blinded samples.

bioRxiv · Mar 20, 2020Microbiology