Author

D. J. Shirley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:virus· 1

Frequent Co-Authors

A. L. Greninger· 2 shared E. A. Bruce· 2 shared J. W. Crothers· 2 shared K. R. Jerome· 2 shared A. Nalla· 1 shared A. Pekosz· 1 shared B. A. Ballif· 1 shared B. A. Johnson· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMicrobiology

A. L. Greninger

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Author profile →

2 papers

Recent·Most cited

Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation

H. C. Kubinski, H. W. Despres, B. A. Johnson, M. M. Schmidt, S. A. Jaffrani, M. G. Mills, K. Lokugamage, C. M. Dumas, D. J. Shirley, L. K. Estes, A. Pekosz, J. W. Crothers, P. Roychoudhury, A. L. Greninger, K. R. Jerome, , E. A. Bruce

The paper identifies a mutation in the SARS-CoV-2 nucleocapsid protein that enhances viral infection by promoting dimer formation and altering virion structure.

bioRxiv · Mar 8, 2024 · PreprintMicrobiology

DIRECT RT-qPCR DETECTION OF SARS-CoV-2 RNA FROM PATIENT NASOPHARYNGEAL SWABS WITHOUT AN RNA EXTRACTION STEP

E. A. Bruce, M.-L. Huang, G. A. Perchetti, S. Tighe, J. J. Hoffman, P. Laaguiby, D. L. Gerrard, A. Nalla, Y. Wei, A. L. Greninger, S. A. Diehl, D. J. Shirley, D. G. B. Leonard, C. D. Huston, B. D. Kirkpatrick, , J. W. Botten

This paper tests a direct RT-qPCR method for detecting SARS-CoV-2 RNA in nasal swabs without RNA extraction, achieving 92% accuracy on blinded samples.

bioRxiv · Mar 20, 2020Microbiology