Author

P. Roychoudhury

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Bioengineering· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 6 Approach:experimental assay· 5 Organism:human· 5 Organism:mouse· 3 Assay:proteomics· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2

Frequent Co-Authors

K. R. Jerome· 6 shared A. L. Greninger· 5 shared H. Xie· 5 shared L. Shrestha· 3 shared M. Huang· 3 shared N. A. P. Lieberman· 3 shared A. Addetia· 2 shared M. A. Loprieno· 2 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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6 shared papersMicrobiology

K. R. Jerome

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Author profile →

10 papers

Recent·Most cited

Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation

H. C. Kubinski, H. W. Despres, B. A. Johnson, M. M. Schmidt, S. A. Jaffrani, M. G. Mills, K. Lokugamage, C. M. Dumas, D. J. Shirley, L. K. Estes, A. Pekosz, J. W. Crothers, P. Roychoudhury, A. L. Greninger, K. R. Jerome, , E. A. Bruce

The paper identifies a mutation in the SARS-CoV-2 nucleocapsid protein that enhances viral infection by promoting dimer formation and altering virion structure.

bioRxiv · Mar 8, 2024 · PreprintMicrobiology

Reanalysis of single-cell RNA sequencing data does not support herpes simplex virus 1 latency in non-neuronal ganglionic cells in mice

W. J. Ouwendijk, P. Roychoudhury, A. L. Cunningham, K. R. Jerome, D. M. Koelle, P. R. Kinchington, I. Mohr, A. C. Wilson, G. M. G. M. Verjans, D. P. Depledge

The paper reanalyzes scRNA-Seq data and finds that HSV-1 latency in non-neuronal ganglionic cells is not supported, attributing the previous findings to technical artifacts.

bioRxiv · Jul 17, 2023Microbiology

Paxlovid-like nirmatrelvir/ritonavir fails to block SARS-CoV-2 transmission in ferrets

R. Cox, C. M. Lieber, J. D. Wolf, A. Karimi, N. A. P. Lieberman, Z. M. Sticher, P. Roychoudhury, M. K. Andrews, R. E. Krueger, M. G. Natchus, G. R. Painter, A. Kolykhalov, A. L. Greninger, R. K. Plemper

This study compares the efficacy of paxlovid and molnupiravir in preventing SARS-CoV-2 transmission in ferrets, finding that molnupiravir reduces transmission while paxlovid does not.

bioRxiv · Nov 20, 2022 · PreprintMicrobiology

Liver humanized NSG-PiZ mice support the study of chronic hepatitis B virus infection and antiviral therapies

R. Colon-Thillet, D. Stone, M. A. Loprieno, L. Klouser, P. Roychoudhury, T. K. Santo, H. Xie, L. Stensland, S. L. Upham, G. Pepper, M. Huang, M. Aubert, K. R. Jerome

This study shows liver-humanized NSG-PiZ mice can support chronic HBV infection and antiviral therapy research, with prolonged viremia and responsiveness to entecavir.

bioRxiv · May 17, 2022 · PreprintMicrobiology

Narrow transmission bottlenecks and limited within-host viral diversity during a SARS-CoV-2 outbreak on a fishing boat

W. H. Hannon, P. Roychoudhury, H. Xie, L. Shrestha, A. Addetia, K. R. Jerome, A. L. Greninger, J. D. Bloom

This study investigates SARS-CoV-2 transmission on a fishing boat, finding low within-host viral diversity and limited viral evolution during the outbreak.

bioRxiv · Feb 9, 2022Evolutionary Biology

In vivo antiviral host response to SARS-CoV-2 by viral load, sex, and age

N. A. P. Lieberman, V. Peddu, H. Xie, L. Shrestha, M. Huang, M. C. Mears, M. N. Cajimat, D. A. Bente, P.-Y. Shi, F. Bovier, P. Roychoudhury, K. R. Jerome, A. Moscona, M. Porotto, A. L. Greninger

This study examines how SARS-CoV-2 induces antiviral host responses, showing differences by viral load, age, and sex in gene expression profiles from infected individuals.

PLOS Biology · Sep 8, 2020Peer-reviewedMicrobiology

SARS-CoV-2 ORF6 disrupts nucleocytoplasmic transport through interactions with Rae1 and Nup98

A. Addetia, N. A. P. Lieberman, Q. Phung, H. Xie, P. Roychoudhury, M. A. Loprieno, M. Huang, L. Shrestha, K. R. Jerome, A. L. Greninger

This paper shows SARS-CoV-2 ORF6 interacts with Rae1 and Nup98 to disrupt nucleocytoplasmic transport, reducing reporter expression and causing nuclear mRNA accumulation, more strongly than SARS-CoV ORF6.

bioRxiv · Aug 3, 2020Microbiology

Elimination of HSV-2 infected cells is mediated predominantly by paracrine effects of tissue-resident T cell derived cytokines

P. Roychoudhury, D. A. Swan, E. Duke, L. Corey, J. Zhu, V. Dave, L. Richert Spuhler, J. M. Lund, M. Prlic, J. Schiffer

The paper shows HSV-2 is controlled by cytokines from tissue-resident T cells, not direct cell killing, even when T-cell numbers are low.

bioRxiv · Apr 18, 2019 · PreprintImmunology

Genomic and proteomic analysis of Human herpesvirus 6 reveals distinct clustering of acute versus inherited forms and reannotation of reference strain

A. Greninger, G. Knudsen, P. Roychoudhury, D. Hanson, R. A. Hall Sedlak, H. Xie, J. Guan, T. Nguyen, V. Peddu, M. Boeckh, M.-L. Huang, L. Cook, D. Depledge, D. Zerr, D. Koelle, , K. Jerome

This study sequences HHV-6B and iciHHV-6 genomes, identifies geographic clustering and recombination in active infections, and reannotates the HHV-6B genome using transcriptomics and proteomics.

bioRxiv · Aug 27, 2017Microbiology

Nitric oxide sensing by chlorophyll a

A. Bhattacharya, P. Kar, P. Biswas, P. Roychoudhury, S. Basu, S. Ghosh, K. Panda, R. Pal, A. K. Dasgupta

The paper proposes using chlorophyll a to sense and classify different nitric oxide species with high sensitivity and temperature dependence.

bioRxiv · Jun 6, 2017Bioengineering