K. R. Jerome

Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation

The paper identifies a mutation in the SARS-CoV-2 nucleocapsid protein that enhances viral infection by promoting dimer formation and altering virion structure.

Viral gene drive spread during herpes simplex virus 1 infection in mice

This study demonstrates that a viral gene drive can spread in vivo during HSV-1 infection in mice by promoting co-infection and recombination.

Reanalysis of single-cell RNA sequencing data does not support herpes simplex virus 1 latency in non-neuronal ganglionic cells in mice

The paper reanalyzes scRNA-Seq data and finds that HSV-1 latency in non-neuronal ganglionic cells is not supported, attributing the previous findings to technical artifacts.

Within-host rhinovirus evolution in upper and lower respiratory tract highlights capsid variability and mutation-independent compartmentalization

This study tracks HRV evolution in immunocompromised patients, finding no genetic adaptation for URT to LRT progression and highlighting capsid variability and mutation-independent compartmentalization.

Liver humanized NSG-PiZ mice support the study of chronic hepatitis B virus infection and antiviral therapies

This study shows liver-humanized NSG-PiZ mice can support chronic HBV infection and antiviral therapy research, with prolonged viremia and responsiveness to entecavir.

Narrow transmission bottlenecks and limited within-host viral diversity during a SARS-CoV-2 outbreak on a fishing boat

This study investigates SARS-CoV-2 transmission on a fishing boat, finding low within-host viral diversity and limited viral evolution during the outbreak.

In vivo antiviral host response to SARS-CoV-2 by viral load, sex, and age

This study examines how SARS-CoV-2 induces antiviral host responses, showing differences by viral load, age, and sex in gene expression profiles from infected individuals.

SARS-CoV-2 ORF6 disrupts nucleocytoplasmic transport through interactions with Rae1 and Nup98

This paper shows SARS-CoV-2 ORF6 interacts with Rae1 and Nup98 to disrupt nucleocytoplasmic transport, reducing reporter expression and causing nuclear mRNA accumulation, more strongly than SARS-CoV ORF6.

DIRECT RT-qPCR DETECTION OF SARS-CoV-2 RNA FROM PATIENT NASOPHARYNGEAL SWABS WITHOUT AN RNA EXTRACTION STEP

This paper tests a direct RT-qPCR method for detecting SARS-CoV-2 RNA in nasal swabs without RNA extraction, achieving 92% accuracy on blinded samples.

Standard Issue: Copy number heterogeneity of JC virus standards discovered through next-generation sequencing

This study identifies copy number heterogeneity in JC virus standards using next-generation sequencing, revealing significant genomic coverage variation due to large deletions.