Author

K. Lokugamage

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. H. Walker· 5 shared V. D. Menachery· 5 shared B. A. Johnson· 4 shared J. A. Plante· 4 shared A. L. Routh· 3 shared C. Schindewolf· 3 shared K. Debbink· 3 shared K. S. Plante· 3 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersMicrobiology

D. H. Walker

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation

H. C. Kubinski, H. W. Despres, B. A. Johnson, M. M. Schmidt, S. A. Jaffrani, M. G. Mills, K. Lokugamage, C. M. Dumas, D. J. Shirley, L. K. Estes, A. Pekosz, J. W. Crothers, P. Roychoudhury, A. L. Greninger, K. R. Jerome, , E. A. Bruce

The paper identifies a mutation in the SARS-CoV-2 nucleocapsid protein that enhances viral infection by promoting dimer formation and altering virion structure.

bioRxiv · Mar 8, 2024 · PreprintMicrobiology

SARS-CoV-2 hijacks fragile X mental retardation proteins for efficient infection

D. Garvanska, R. E. Alvarado, F. Mundt, E. Nilsson, J. Duel, F. Coscia, R. Lindqvist, K. Lokugamage, B. Johnson, J. A. Plante, D. R. Morris, M. N. Vu, L. Estes, A. McLeland, J. Walker, , J. Nilsson

This study identifies a novel interaction between SARS-CoV-2 NSP3 and FMRPs, showing that this interaction is critical for viral replication and disease progression.

bioRxiv · Sep 1, 2023 · PreprintMicrobiology

SARS-CoV-2 Uses Nonstructural Protein 16 to Evade Restriction by IFIT1 and IFIT3

C. Schindewolf, K. Lokugamage, M. Vu, B. A. Johnson, D. Scharton, J. A. Plante, B. K. Kalveram, P. A. Crocquet-Valdes, S. L. Sotcheff, E. Jaworski, R. E. Alvarado, K. Debbink, M. D. Daugherty, S. Weaver, A. L. Routh, , V. D. Menachery

This paper shows that SARS-CoV-2's NSP16 protein helps evade immune detection by methylating viral mRNA, and disrupting this function reduces viral replication and disease in hamsters.

bioRxiv · Sep 26, 2022Microbiology

QTQTN motif upstream of the furin-cleavage site plays key role in SARS-CoV-2 infection and pathogenesis.

M. N. Vu, K. Lokugamage, J. A. Plante, D. Scharton, B. A. Johnson, S. Sotcheff, D. Swetnam, C. Schindewolf, R. E. Alvarado, P. A. Crocquet-Valdes, K. Debbink, S. Weaver, D. H. Walker, A. L. Routh, K. S. Plante, V. D. Menachery

This study shows that deleting the QTQTN motif reduces SARS-CoV-2 replication and disease by affecting spike processing and glycosylation.

bioRxiv · Dec 15, 2021Microbiology

Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge

A. Muruato, M. Vu, B. A. Johnson, M. Davis-Gardner, A. R. Vanderheiden, K. Lokugamage, C. Schindewolf, P. A. Crocquet-Valdes, R. M. Langsjoen, J. A. Plante, K. S. Plante, S. C. Weaver, K. Debbink, A. L. Routh, D. H. Walker, , V. D. Menachery

This study creates a mouse-adapted SARS-CoV-2 strain that protects mice from lethal SARS-CoV challenge, demonstrating cross-strain immunity.

bioRxiv · May 3, 2021Microbiology