V. D. Menachery

Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation

The paper identifies a mutation in the SARS-CoV-2 nucleocapsid protein that enhances viral infection by promoting dimer formation and altering virion structure.

SARS-CoV-2 hijacks fragile X mental retardation proteins for efficient infection

This study identifies a novel interaction between SARS-CoV-2 NSP3 and FMRPs, showing that this interaction is critical for viral replication and disease progression.

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication

This study identifies the role of G3BP1-N interaction in SARS-CoV-2 replication by showing that disrupting this interaction reduces viral replication and pathogenesis.

The impact of RSV/SARS-CoV-2 co-infection on clinical disease and viral replication: insights from a BALB/c mouse model

This study investigates how RSV and SARS-CoV-2 co-infection affects clinical disease and viral replication in mice, finding that infection timing and viral dose influence disease outcomes.

Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection

This study identifies the N679K mutation in Omicron variants as reducing spike protein expression and attenuating SARS-CoV-2 infection, while showing a replication advantage in the upper airway.

SARS-CoV-2 Uses Nonstructural Protein 16 to Evade Restriction by IFIT1 and IFIT3

This paper shows that SARS-CoV-2's NSP16 protein helps evade immune detection by methylating viral mRNA, and disrupting this function reduces viral replication and disease in hamsters.

Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis.

This study shows that mutations in the SARS-CoV-2 nucleocapsid protein enhance viral replication and pathogenesis by increasing phosphorylation and resisting kinase inhibition.

A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions

This paper describes a live-attenuated SARS-CoV-2 vaccine candidate with deleted ORFs that shows reduced replication and attenuation in animal models, and reports its protective efficacy against wild-type virus challenge.

Engineering SARS-CoV-2 cocktail antibodies into a bispecific format improves neutralizing potency and breadth

This study engineers bispecific antibodies against SARS-CoV-2, showing that one design outperforms a cocktail in neutralizing activity and breadth against variants.

QTQTN motif upstream of the furin-cleavage site plays key role in SARS-CoV-2 infection and pathogenesis.

This study shows that deleting the QTQTN motif reduces SARS-CoV-2 replication and disease by affecting spike processing and glycosylation.

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

This study identifies the P681R mutation in the Delta variant's spike protein as critical for enhanced viral replication compared to the Alpha variant through increased furin cleavage of the spike protein.

Common Mechanism of SARS-CoV and SARS-CoV-2 Pathogenesis across Species

The paper identifies host susceptibility loci for SARS-CoV and SARS-CoV-2 using GWAS and Collaborative Cross datasets, validating CCR9 as a key regulator of severe disease outcomes across species.

Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge

This study creates a mouse-adapted SARS-CoV-2 strain that protects mice from lethal SARS-CoV challenge, demonstrating cross-strain immunity.

CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection

This study identifies a CCR2-dependent monocyte-derived cell mechanism that restricts SARS-CoV-2 infection and inflammation in the lungs of mice.

Nucleocapsid vaccine elicits spike-independent SARS-CoV-2 protective immunity

This study shows that a nucleocapsid protein vaccine provides protective immunity against SARS-CoV-2, independent of spike protein targeting, in animal models.

Endomembrane targeting of human OAS1 p46 augments antiviral activity

This study shows that the OAS1 p46 isoform, targeted to the endomembrane system, enhances antiviral activity against RNA viruses and is associated with COVID-19 severity.

The N501Y spike substitution enhances SARS-CoV-2 transmission

The paper shows the N501Y spike mutation in SARS-CoV-2 enhances viral transmission in hamsters and human airway cells by increasing receptor binding affinity.

Neutralization of spike 69/70 deletion, E484K, and N501Y SARS-CoV-2 by BNT162b2 vaccine-elicited sera

The paper evaluates the neutralization effect of BNT162b2 vaccine-elicited sera against SARS-CoV-2 variants with specific spike mutations.

A trans-complementation system for SARS-CoV-2

This paper develops a trans-complementation system to produce single-round infectious SARS-CoV-2 at BSL-2 labs, enabling safe high-throughput testing without full viral replication.

Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera

The paper assesses the neutralizing activity of BNT162b2 vaccine-elicited sera against N501Y and Y501 SARS-CoV-2 variants, finding equivalent neutralizing titers.

Type I interferon susceptibility distinguishes SARS-CoV-2 from SARS-CoV.

This study compares the sensitivity of SARS-CoV-2 and SARS-CoV to type I interferon, finding SARS-CoV-2 is more susceptible to IFN-I treatment.

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium

This study investigates SARS-CoV-2 tropism, antiviral responses, and therapy effectiveness in human airway epithelium using single-cell RNA-sequencing and flow cytometry.

A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19

This paper develops a high-throughput assay using a nanoluciferase-modified SARS-CoV-2 virus to rapidly test neutralizing antibodies and antiviral drugs.

Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection

The paper shows that baseline T cell immune signatures in mice predict virologic and disease outcomes upon SARS-CoV infection.

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

This study shows the D614G mutation in SARS-CoV-2 increases viral replication and upper respiratory tract viral loads but does not reduce vaccine efficacy or antibody neutralization.

Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis

This study shows that removing the furin cleavage site from SARS-CoV-2 increases replication in Vero cells but reduces replication in respiratory cells and pathogenesis in hamsters, while also decreasing neutralization susceptibility.

SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with non-severe disease

The paper assesses SARS-CoV-2 neutralization and serology in convalescent plasma from non-severe COVID-19 donors, finding correlations between binding activity and neutralization.

Modified Vaccinia Ankara Based SARS-CoV-2 Vaccine Expressing Full-Length Spike Induces Strong Neutralizing Antibody Response

This study develops two MVA-based SARS-CoV-2 vaccines, MVA/S and MVA/S1, and finds that MVA/S induces stronger neutralizing antibodies against SARS-CoV-2 compared to MVA/S1.

Novel ionophores active against La Crosse virus identified through rapid antiviral screening

This paper identifies novel antivirals, including valinomycin, active against La Crosse virus and other viruses by disrupting potassium ion homeostasis.

A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation

This paper develops a high-throughput fluorescence-based assay to measure SARS-CoV-2 neutralizing antibodies, showing comparable results to the gold standard plaque reduction neutralizing assay.