Immunosuppression broadens evolutionary pathways to treatment failure during Acinetobacter baumannii pneumonia
W. Huo, L. M. Busch, J. Hernandez-Bird, E. Hamami, C. W. Marshall, E. Geisinger, V. S. Cooper, T. van Opijnen, J. Rosch, R. R. Isberg
This study shows that immunosuppression promotes antibiotic resistance evolution in Acinetobacter baumannii pneumonia by enabling persistence mutations that cause treatment failure without clinical resistance.
bioRxiv · Apr 7, 2021 · PreprintMicrobiology