Author

E. Geisinger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9

Signature Assays, Organisms & Methods

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Organism:Arabidopsis· 6 Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Approach:genetic perturbation / CRISPR· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

R. R. Isberg· 6 shared T. van Opijnen· 5 shared S. Syal· 4 shared Y. Dai· 4 shared E. Hamami· 3 shared J. Bai· 3 shared W. Huo· 3 shared A. Farinha· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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6 shared papersMicrobiology

R. R. Isberg

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Author profile →

9 papers

Recent·Most cited

A phosphorylation signal activates genome-wide transcriptional control by BfmR, the global regulator of Acinetobacter resistance and virulence.

N. Raustad, Y. Dai, A. Iinishi, A. Mohapatra, M. W. Soo, E. Hay, G. M. Hernandez, E. Geisinger

This study identifies how phosphorylation activates BfmR to regulate gene expression, antibiotic resistance, and virulence in Acinetobacter baumannii.

bioRxiv · Jun 16, 2024 · PreprintMicrobiology

Loss of essential outer membrane functions causes drug hypersensitization in Acinetobacter baumannii overexpressing multidrug efflux pumps

E. Hamami, W. Huo, K. Neal, I. Neisewander, S. Fnu, J. S. Freundlich, E. Geisinger, R. R. Isberg

The paper identifies essential genes in Acinetobacter baumannii that support efflux pump overproducer fitness during ciprofloxacin treatment, revealing roles in outer membrane integrity and pH homeostasis.

bioRxiv · Jan 4, 2024Microbiology

Identification of Determinants that Allow Maintenance of High-Level Fluoroquinolone Resistance in Acinetobacter baumannii

E. Hamami, W. Huo, A. Castaneda, J. Bai, S. Syal, J. C. Ortiz-Marquez, T. van Opijnen, E. Geisinger, R. R. Isberg

The paper identifies proteins essential for maintaining fitness in Acinetobacter baumannii strains overexpressing RND efflux pumps, highlighting the role of outer membrane integrity and compensatory mechanisms.

bioRxiv · Oct 3, 2023 · PreprintMicrobiology

Genome-wide phage susceptibility analysis in Acinetobacter baumannii reveals capsule modulation strategies that determine phage infectivity

J. Bai, N. Raustad, J. Denoncourt, T. van Opijnen, E. Geisinger

This study identifies capsule modulation strategies in Acinetobacter baumannii that determine phage infectivity using Tn-seq and genetic analysis.

bioRxiv · Oct 17, 2022 · PreprintMicrobiology

A new class of cell wall-recycling L,D-carboxypeptidase determines β-lactam susceptibility and morphogenesis in Acinetobacter baumannii

Y. Dai, V. Pinedo, A. Y. Tang, F. Cava, E. Geisinger

This paper identifies ElsL as a novel L,D-carboxypeptidase in A. baumannii essential for cell wall recycling, antibiotic resistance, and morphogenesis.

bioRxiv · Sep 22, 2021Microbiology

Immunosuppression broadens evolutionary pathways to treatment failure during Acinetobacter baumannii pneumonia

W. Huo, L. M. Busch, J. Hernandez-Bird, E. Hamami, C. W. Marshall, E. Geisinger, V. S. Cooper, T. van Opijnen, J. Rosch, R. R. Isberg

This study shows that immunosuppression promotes antibiotic resistance evolution in Acinetobacter baumannii pneumonia by enabling persistence mutations that cause treatment failure without clinical resistance.

bioRxiv · Apr 7, 2021 · PreprintMicrobiology

Essential gene analysis in Acinetobacter baumannii by high-density transposon mutagenesis and CRISPR interference

J. Bai, Y. Dai, A. Farinha, A. Y. Tang, S. Syal, G. Vargas-Cuebas, D. Surujon, R. R. Isberg, T. van Opijnen, E. Geisinger

This study identifies essential genes in Acinetobacter baumannii using transposon mutagenesis and a CRISPRi system, revealing new factors and conditionally essential processes.

bioRxiv · Sep 15, 2020Microbiology

Antibiotic hypersensitivity signatures identify targets for attack in the Acinetobacter baumannii cell envelope

E. Geisinger, N. J. Mortman, Y. Dai, M. Cokol, S. Syal, A. Farinha, D. Fisher, A. Tang, D. W. Lazinski, S. Wood, J. Anthony, T. Opijnen, R. R. Isberg

This study identifies antibiotic hypersensitivity signatures in A. baumannii to discover new targets for attacking the pathogen's cell envelope.

bioRxiv · Mar 11, 2020Microbiology

The landscape of intrinsic and evolved fluoroquinolone resistance in Acinetobacter baumannii includes suppression of drug-induced prophage replication

E. Geisinger, G. Vargas-Cuebas, N. J. Mortman, S. Syal, E. Wainwright, D. W. Lazinski, S. Wood, Z. Zhu, J. Anthony, T. van Opijnen, R. R. Isberg

This paper identifies mutations that alter fluoroquinolone sensitivity in Acinetobacter baumannii and shows that preferential Topo IV poisoning leads to prophage induction and SOS response activation.

bioRxiv · Oct 14, 2018 · PreprintMicrobiology