Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer
S. A. Hutchinson, A. Websdale, P. Lianto, G. Cioccoloni, H. Roberg-Larsen, B. Kim, A. Rose, C. Soteriou, L. M. Wastall, B. Williams, M. Henn, J. J. Chen, L. Ma, J. B. Moore, E. R. Nelson, , J. L. Thorne
This study identifies LXRalpha as a driver of chemoresistance in TNBC through its regulation of P-glycoprotein, linking cholesterol metabolism to chemotherapy failure.
bioRxiv · Aug 4, 2020Cancer Biology