Author

H. Roberg-Larsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:clinical cohort / trial· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1

Frequent Co-Authors

J. L. Thorne· 3 shared A. Aizenshtadt· 2 shared A. Websdale· 2 shared G. Cioccoloni· 2 shared S. Krauss· 2 shared S. R. Wilson· 2 shared T. A. Hughes· 2 shared A. Rose· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

J. L. Thorne

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mass Spectrometry Reveals that Oxysterols are Secreted from Non-Alcoholic Fatty Liver Disease Induced Organoids

K. S. Komurcu, I. Wilhelmsen, J. L. Thorne, S. Krauss, S. R. Wilson, A. Aizenshtadt, H. Roberg-Larsen

The paper uses mass spectrometry to show that liver organoids secrete oxysterols, with 26-hydroxycholesterol being elevated in steatotic organoids and potentially acting as a biomarker for NAFLD.

bioRxiv · Feb 22, 2023Biochemistry

Pharmacologic and genetic inhibition of cholesterol esterification reduces tumour burden: a pan-cancer systematic review and meta-analysis of preclinical models

A. Websdale, Y. Kiew, P. Chalmers, X. Chen, G. Cioccoloni, T. A. Hughes, X. Luo, R. Mwarazi, M. Poirot, H. Roberg-Larsen, R. Wu, M. Xu, M. A. Zulyniak, J. L. Thorne

This paper reviews preclinical studies showing that inhibiting cholesterol esterification reduces tumour burden across cancers, with SOAT inhibitors like avasimibe showing promise.

bioRxiv · Jun 12, 2021Cancer Biology

"Organoid-in-a-column" coupled on-line with liquid chromatography-mass spectrometry

S. Kogler, A. Aizenshtadt, S. Harrison, F. S. Skottvoll, H. E. Berg, S. Abadpour, H. Scholz, G. Sullivan, B. Thiede, E. Lundanes, I. L. Bogen, S. Krauss, H. Roberg-Larsen, S. R. Wilson

This paper demonstrates the integration of liver organoids with liquid chromatography-mass spectrometry for on-line drug metabolism analysis.

bioRxiv · Sep 8, 2020Bioengineering

Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer

S. A. Hutchinson, A. Websdale, P. Lianto, G. Cioccoloni, H. Roberg-Larsen, B. Kim, A. Rose, C. Soteriou, L. M. Wastall, B. Williams, M. Henn, J. J. Chen, L. Ma, J. B. Moore, E. R. Nelson, , J. L. Thorne

This study identifies LXRalpha as a driver of chemoresistance in TNBC through its regulation of P-glycoprotein, linking cholesterol metabolism to chemotherapy failure.

bioRxiv · Aug 4, 2020Cancer Biology