J. L. Thorne

Mass Spectrometry Reveals that Oxysterols are Secreted from Non-Alcoholic Fatty Liver Disease Induced Organoids

The paper uses mass spectrometry to show that liver organoids secrete oxysterols, with 26-hydroxycholesterol being elevated in steatotic organoids and potentially acting as a biomarker for NAFLD.

Convergent evolution of polyploid genomes from across the eukaryotic tree of life

This study models gene loss in polyploid genomes across eukaryotes, showing convergent evolutionary patterns and reciprocal gene loss barriers.

Pharmacologic and genetic inhibition of cholesterol esterification reduces tumour burden: a pan-cancer systematic review and meta-analysis of preclinical models

This paper reviews preclinical studies showing that inhibiting cholesterol esterification reduces tumour burden across cancers, with SOAT inhibitors like avasimibe showing promise.

Comprehensive profiling of liver x receptor splicing in triple negative breast cancer reveals existence of novel splice variants that are prognostic for survival

The paper identifies novel LXR splice variants in triple negative breast cancer and shows their prognostic significance for patient survival.

Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer

This study identifies LXRalpha as a driver of chemoresistance in TNBC through its regulation of P-glycoprotein, linking cholesterol metabolism to chemotherapy failure.

Pedigree-based measurement of the de novo mutation rate in the gray mouse lemur reveals a high mutation rate, few mutations in CpG sites, and a weak sex bias

The paper estimates the de novo mutation rate in gray mouse lemurs using linked-read sequencing and finds a high mutation rate, few mutations in CpG sites, and a weak sex bias.