Author

L. McAlary

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:zebrafish· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. J. Yerbury· 2 shared M. G. Duval· 2 shared S. S. Plotkin· 2 shared W. T. Allison· 2 shared A. Dijkstra· 1 shared A. K. Walker· 1 shared A. Y. Roman· 1 shared D. Cox· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

J. J. Yerbury

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Author profile →

4 papers

Recent·Most cited

A copper chaperone-mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis

L. McAlary, V. K. Shephard, G. S. Wright, J. J. Yerbury

This study shows that combining CuATSM and ebselen reduces SOD1 aggregation and cell death in a cell model of ALS.

bioRxiv · Feb 22, 2021 · PreprintBiochemistry

Tryptophan residues in TDP-43 and SOD1 mediate the cross-seeding and toxicity of SOD1

E. Pokrishevsky, M. G. Duval, L. McAlary, S. Louadi, S. Pozzi, A. Y. Roman, S. S. Plotkin, A. Dijkstra, J.-P. Julien, W. T. Allison, N. R. Cashman

This study identifies tryptophan residues in SOD1 and TDP-43 that mediate cross-seeding and toxicity in ALS, suggesting a druggable target for therapeutic intervention.

bioRxiv · Jul 27, 2020 · PreprintCell Biology

Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal-like cells

R. San Gil, D. Cox, L. McAlary, T. Berg, A. K. Walker, J. J. Yerbury, L. Ooi, H. Ecroyd

This study shows that neurodegenerative disease-associated protein aggregates fail to induce the heat shock response in neuronal-like cells, unlike non-pathogenic aggregation-prone proteins.

bioRxiv · Jan 6, 2020Cell Biology

In Silico Determined Properties of Designed Superoxide Dismutase-1 Mutants Predict ALS-like Phenotypes In Vitro and In Vivo

M. G. DuVal, L. McAlary, M. Habibi, P. Garg, M. Sher, N. Cashman, W. T. Allison, S. S. Plotkin

The paper designs and tests SOD1 mutants using computational methods, showing that a destabilizing mutant causes ALS-like phenotypes while a stabilizing mutant rescues them in zebrafish.

bioRxiv · Nov 21, 2018 · PreprintBiophysics